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Study: Stem Cells May Reverse MS Damage

It's been a good month for multiple sclerosis research. As I blogged on Friday, the first oral MS drug -- an appealing and apparently effective alternative to the existing injectable therapies -- is nearing approval.

That same day The Lancet Neurology published research in which 21 people with early-stage relapsing/remitting MS were treated with stem-cell therapy to remarkable effect: Not only did the transplantation of stem cells appear to reduce relapses and curb disease progression dramatically, it also seems to have reversed some of the neurological damage caused by the disease.

It's a small study that needs big-time followup. (Recruitment for a larger, controlled trial is underway.) But the research, conducted by scientists led by Richard Burt at Northwestern University, represents a breakthrough. It's been thought that stem-cell technology could be harnessed to halt MS's progressive assault on the central nervous system. Earlier studies among people with later-stage MS, though, had shown little benefit from stem-cell treatment -- not enough to warrant taking the risks stem-cell therapy can pose. The new research suggests that the trick is to intervene early, before the disease moves to its unremitting, progressive stage, and to use a milder course of stem-cell treatment.

Also remarkable is the fact that the study was done using haemopoietic stem cells -- culled from the subjects' own bone marrow. Though President Obama's anticipated relaxation of rules regarding federal funding of stem-cell research is expected to broaden the field by making more embryonic stem cells available, the Northwestern research demonstrates that much can be done with other, less controversial lines of cells. The new research was funded entirely by the university.

This work's not without risks. Though none of the folks in the study suffered lasting side effects, all of them took a fairly big gamble. Before the harvested stem cells could be reimplanted, each participant had his or her entire immune system wiped out, rendering each person completely defenseless against infection for a brief time. That got rid of the misguided immune-system cells that for unknown reasons attack the nervous system as if it were a foreign invader and gave the new cells a clean slate upon which to work their magic.

The study's authors note that as it stands, stem-cell therapy isn't (yet) a cure for this unpredictable and often debilitating disease. But it sure is a bright ray of hope.

By Jennifer LaRue Huget  |  February 2, 2009; 7:00 AM ET
Categories:  Chronic Conditions  
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Comments

I wanted to provide a little more information for those that are interested. Here are four respected treatment centers currently treating MS:
1 Center for Cellular Therapy at Tel Aviv Israel
2 Dr. Roberto Fernandez Vina El Salvador
3 Xcell-Center Germany
4 Beike Biotechnology China

Here is a site whose mission is to educate and inform the public about the rapid advances being made in Adult Stem Cell research so they can intelligently exercise their freedom of choice in medical care.
http://repairstemcells.org/

Here is the URL for the clinical trials (past and present) in the U.S. for MS:
http://clinicaltrials.gov/ct2/results?term=ADULT+STEM+CELL+multiple+sclerosis&recr=&rslt=&type=&cond=&intr=&spons=&id=&state1=&cntry1=&state2=&cntry2=&state3=&cntry3=&locn=&rcv_s=&rcv_e=&lup_s=&lup_e=

Here are some early adult stem cell studies on MS:
Saccardi R et al., Autologous HSCT for severe progressive multiple sclerosis in a multicenter trial: impact
on disease activity and quality of life, Blood 105, 2601-2607, 15 March 2005

Burt RK et al., “Induction of tolerance in autoimmune diseases by hematopoietic stem cell transplantation:
getting closer to a cure?”, Blood 99, 768-784, 1 February 2002
Updated: 4/11/2007

Mancardi GL et al.; “Autologous hematopoietic stem cell transplantation suppresses Gd-enhanced MRI
activity in MS”; Neurology 57, 62-68; July 10, 2001

Rabusin M et al.; “Immunoablation followed by autologous hematopoietic stem cell infusion for the
treatment of severe autoimmune disease”; Haematologica 85(11 Suppl), 81-85; Nov. 2000

Burt, RK and Traynor, AE; “Hematopoietic Stem Cell Transplantation: A New Therapy for Autoimmune
Disease”; Stem Cells17, 366-372; 1999

Burt RK et al.; “Hematopoietic stem cell transplantation of multiple sclerosis, rheumatoid arthritis, and
systemic lupus erythematosus”; Cancer Treat. Res. 101, 157-184; 1999

Posted by: dsgrano | February 2, 2009 2:15 PM | Report abuse

Adult stem cells have peer review studies with great results. Below are published reports. Adult Stem Cells are here for you today with "StemEnhance" two capsules will release 3 - 4 million additional adult stem cells from your bone marrow in 30 to 60 minutes. This is also prove by a peer review study. An all natural botonial extract. www.adultstemcellsrelease.com
google me ray mumme

NEURAL DEGENERATIVE DISEASES & INJURIES
STROKE
Shyu W-C et al., Granulocyte colony-stimulating factor for acute ischemic stroke: a randomized controlled
trial, Canadian Medical Association Journal 174, 927-933, 28 March 2006
Stilley CS et al., Changes in cognitive function after neuronal cell transplantation for basal ganglia stroke,
Neurology 63, 1320-1322, October 2004
Meltzer CC et al.; “Serial [18F]Fluorodeoxyglucose Positron Emission Tomography after Human Neuronal
Implantation for Stroke”; Neurosurgery 49, 586-592; 2001.
Kondziolka D et al.; “Transplantation of cultured human neuronal cells for patients with stroke”;
Neurology 55, 565-569; August 2000
Updated: 4/11/2007
PARKINSON’S DISEASE
USING DIRECT STIMULATION OF PATIENTS’ ENDOGENOUS ADULT NEURAL
STEM CELLS:
Love S et al., Glial cell line-derived neurotrophic factor induces neuronal sprouting in human brain, Nature
Medicine 11, 703-704, July 2005
Slevin JT et al., Improvement of bilateral motor functions in patients with Parkinson disease through the
unilateral intraputaminal infusion of glial cell line-derived neurotrophic factor, Journal of
Neurosurgery 102, 216-222, February 2005
Gill SS et al.; “Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease”;
Nature Medicine 9, 589-595; May 2003 (published online 31 March 2003)
SPINAL CORD INJURY
Lima C et al., Olfactory mucosa autografts in human spinal cord injury: A pilot clinical study, Journal of
Spinal Cord Medicine 29, 191-203, July 2006

Posted by: raymumme | February 3, 2009 8:25 AM | Report abuse

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